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Study links endodontic disease with heart disease

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drsantoshpatil's picture
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A study published in Journal of the American Dental Association suggests that endodontic disease may increase a person's risk of heart disease.

The retrospective multicenter study found a correlation between people who reported having had endodontic therapy and those who had coronary heart disease (JADA, August 2009, Vol. 140:8, pp. 1004-1012).

Numerous studies have shown that periodontal disease contributes to the risk of heart disease, diabetes, and many other illnesses. Though the connection is not fully understood, several researchers have proposed that inflammation triggered by periodontal bacteria affects other systems.

Since similar bacteria inflame endodontic tissue, investigators in the current study wondered if they might also affect patients' cardiovascular health.

Analyzing data from the Atherosclerosis Risk in Communities study sponsored by the National Heart, Blood, and Lung Institute, the investigators tested the correlation between patients who said they had had endodontic treatment and those who had experienced coronary heart disease.

They found that among participants with 25 or more teeth, those who reported having had endodontic treatment twice or more had 1.62 times (95% confidence interval 1.04-2.53) the odds of prevalent heart disease as those who never had endodontic treatment.

They theorized that those with 24 or fewer teeth might have had many extracted for reasons other than caries, and as a result these groups did not experience the inflammation that affected heart disease risk.

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drmithila's picture
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Study links endodontic disease with heart disease

 cross-sectional study was designed to explore a possible association between endodontic disease variables and coronary heart disease (CHD). Dental infections are hypothesized to be linked to atherosclerosis and could be a cause of vascular changes crucial for the development of CHD. Most studies have focused on periodontal disease. To our knowledge, no one has specifically studied endodontic variables as risk factors for the development of CHD. In 1992-93, a representative sample (n = 1056) of women in Göteborg, Sweden, aged between 38 and 84 years, took part in a combined dental and medical survey. The dependent variable was CHD, i.e. subjects with angina pectoris and/or a history of myocardial infarction (n = 106). The independent variables were number of root-filled teeth (RF), number of teeth with periapical radiolucencies (PA), tooth loss (TL), age, life situation, marital status, smoking, alcohol habits, body mass index, waist-hip ratio, serum cholesterol and triglyceride concentrations, hypertension and diabetes. The multivariate logistic regression analysis did not prove the endodontic variables to be predictive of CHD. Only age and tooth loss were significantly associated with CHD, with OR = 1.07 (CI = 1.03-1.12) and OR = 2.70 (CI = 1.49-4.87), respectively. The bivariate logistic regression analysis showed a positive significant association between subjects with RF = 2 and CHD, but for PA the bivariate analysis did not support an association with CHD. This cross-sectional study did not reveal a significant association between endodontically treated teeth and CHD nor between teeth with periapical disease and CHD.

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