Small amounts of the element zinc are essential to the proper functioning of nearly every body system, but too much can be toxic. Some patients develop neurological problems from zinc. Toxicity from zinc also can be manifested as nausea, stomachache, and mouth irritation. The authors reviewed and analyzed a wide range of information now available to dentists and physicians on the use of zinc in dentistry. Many dental patients are regularly exposed to zinc from certain restorative materials, mouthwashes, toothpastes, and denture adhesives. "Dentists are suddenly hungry for more information on zinc," said co-author Nasir Bashirelahi, PhD. "It is used in dental products abundantly, especially denture adhesives or pastes." Growing concern with denture adhesives may tip the decisions of some patients away from getting fitted with dentures, which may require perpetual pasting to the gums, to opting for dental implants instead, typically a more expensive choice, he said. In this report, Dr. Patel wrote, "Of direct concern to dental professionals…has been the recent discovery of neurologic disorders resulting from excessive use of denture adhesives, having high leachable zinc contents which can cause copper deficiencies." The authors explain that the link of excessive zinc intake has been related to copper insufficiency due to the competition in absorption patterns for the 2 metals in the gastrointestinal tract. According to the paper, several studies link copper deficient anemia and neutropenia with an increase of zinc intake. " They also urge dentists to thoroughly understand the relationship among zinc, health, and dental products because of "legal ramifications."
Presently there are zinc-free dental adhesives on the market. " Zinc plays an important role in human physiology, as it is involved in the proper functioning of the immune system, cellular growth, cell division and normal cell death (a replacement system). The element also plays a key patho-physiological role in major neurological disorders as well as diabetes. Zinc deficiency is a worldwide problem, whereas excessive dietary intake of zinc is relatively rare. Dr. Bashirelahi, who is a molecular endocrinologist, says that among the principal roles of zinc is proper function of the pancreatic system. Another zinc-dependent process is spermatogenesis, as zinc is important for testosterone metabolism.