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Newly Discovered Condition Adversely Impacts Teeth

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sushantpatel_doc's picture
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Joined: 30 Nov 2009

A new, recessively inherited syndrome features extra teeth and delayed tooth eruption, among other problems like craniosynostosis and maxillary hyperplasia. A causative mutation was also pointed out in this gene, IL11RA.

The appearance of extra teeth is one of the most common things seen with this condition. Dental surgery is necessary to combat the problem in almost all cases.

Four children from a Pakistani family living in Denmark displayed the condition. The teeth developed in a manner that indicated a third set of teeth was on the way, something that is rare for humans.

The parents of the children were first cousins, making it more possible to localize the gene and increase the children’s chances of developing this condition. It also made it easier for researchers to pinpoint where the mutation occurred. The issue was the changing of a single amino acid in the gene for interleukin 11 receptor alpha.

There are cases of patients in England and The Nerthlands also displaying this condition.

The main thing researchers found from this study is that the gene IL11RA is essential when it comes to the eruption of permanent teeth and skull formation.

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