Register for a seminar by DR. VEERENDRA DARAKH on EFFECTIVE PATIENT COMMUNICATION on 26th November on : [email protected] 

  • Sharebar

Anti-arthritics can exacerbate other inflammatory diseases like periodontitis

No replies
MOHANNAD's picture
Offline
Joined: 4 Jun 2014

Inflammatory diseases can occur simultaneously in distinct sites in the same patient, complicating treatment because a medication effective for one disorder may exacerbate the other. One such example is the anti-arthritic medication dexamethasone, which alleviates joint disease but can worsen periodontal bone disease. A study in the August issue of The American Journal of Pathology highlights the effects of a new class of anti-arthritic drugs, specifically DTrp8-ɣMSH (DTrp), that acts via the melanocortin (MC) system to reduce both arthritic joint inflammation and periodontitis.

Mauro Perretti, PhD, of Queen Mary University of London, Barts, and The London School of Medicine and Dentistry (UK).says:

"This research, a joint program with the Universidade Federal de Minas Gerais in Brazil, indicates that MC receptor agonists, possibly better if selective for MC3, represent a novel class of anti-arthritic therapeutics able to target joint disease without aggravating unwanted effects on distant organs and tissues,"

More than 60 years ago, adrenocorticotropic hormone (ACTH) was shown to be effective for treating rheumatoid and gouty arthritis, yet its current clinical use is very sporadic. It is now appreciated that some of the anti-inflammatory actions of ACTH are mediated via the peripheral MC system on MC receptors expressed in bone cells, fibroblasts, and immune cells. Research has shown that activation of MC receptors by ACTH or other MC peptides can lead to a variety of protective actions against bone loss, including increased matrix deposition, reduced osteoclast activation, and enhanced proliferation of bone-forming cells.

In this study, researchers first determined whether mice that were induced with experimental arthritis also manifested bone loss in the alveolar (tooth socket) bone. They found that bone loss in the jaw correlated with the severity of localized inflammation in the joints of the mice.

continue reading here http://asnanportal.com/index.php/reports/news/624-anti-arthritics

Sincerely
Dr.Mohannad Kiswani
BDS MSC Health Service
Managing Director at
www.asnanportal.com

up
0 users have Like. User Likes

Sincerely
Dr.Mohannad Kiswani
BDS MSC Health Service
Managing Director at
www.asnanportal.com